Pesquisa sobre: ANAPHASE-PROMOTING COMPLEX-CYCLOSOME 
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Descritor Inglês:   Anaphase-Promoting Complex-Cyclosome 
Descritor Espanhol:   Ciclosoma-Complejo Promotor de la Anafase 
Descritor Português:   Ciclossomo-Complexo Promotor de Anáfase 
Sinônimos Inglês:   Anaphase Promoting Complex  
Categoria:   D08.811.464.938.750.092
D12.776.167.024
Definição Inglês:   An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability. 
Nota Histórica Inglês:   2014 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   55272 
Identificador Único:   D064173 

Ocorrência na BVS:
 

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